Principal Investigator

Name:

Yu-Fen Huang

Education

2007 – 2009 Post-doctoral fellowship

Department of Chemistry, University of Florida, USA,

2002 – 2006 Ph.D. in Analytical Chemistry

Department of Chemistry, National Taiwan University, Taiwan

Tel:

+886-3-5715131 ext 34212

Email:

yufen@mx.nthu.edu.tw

Website:

http://m100.nthu.edu.tw/~s100012516/

Research Interests

Biomedical application of nanotechnology is one of the most promising ways for developing new drug delivery strategies, improvements in diagnosis and overcoming crucial limitations in disease treatment normally faced in clinical trials.  Nanotheranostic has been considered as a more efficient therapeutic strategy than common drug treatments. Our current research focuses on the development of new nanocomposites based on gold and iron nanoparticles, nanorods, and core-shell nanostructures toward multifunctional platforms for tumor cells targeting, drug delivery, gene delivery, and cancer theranostic therapy. Remote controlled release systems responsive to external stimuli such as light, pH, ROS, ultrasound and electric field were also studied to achieve efficient drug/gene release.

Honors and Awards

1. Young Faculty Research Award of National Tsing Hua University, 2012

2. Academic Achievement Award of National Tsing Hua University, 2010, 2012, 2013, 2014

3. Outstanding Publication Award of National Tsing Hua University, 2012, 2013

Selected Publications

1. Shiao, Y.-S.; Chiu, H.-H.; Wu, P.-H.; Huang, Y.-F.*, Aptamer-Functionalized Gold Nanoparticles As Photoresponsive Nanoplatform for Co-Drug Delivery. ACS Appl. Mater. Interfaces 2014, 6, 21832-21841.

2. Wang, C.-H., Kang, S.-T., Lee, Y.-H., Luo, Y.-L., Huang, Y.-F., and Yeh, C.-K.* “Aptamer-conjugated and Drug-Loaded Acoustic Droplets for Ultrasound Theranosis.” Biomaterials 2012, 33, 1939-1947.

3. Luo, Y.-L., Shiao, Y.-S., and Huang, Y.-F.* “Release of Photoactivatable Drugs from Plasmonic Nanoparticles for Targeted Cancer Therapy.” ACS Nano 2011, 5, 7796-7804.

4. Kang, H., Trondoli, A. C., Zhu, G., Chen, Y., Chang, Y.-J., Liu, H., Huang, Y.-F.*, Zhang, X.*, and Tan, W.* “Near-infrared Light-responsive Core-shell Nanogels for Targeted Drug Delivery.” ACS Nano 2011, 5, 5094-5099.

5. Chang, H.-Y., Hsiung, T.-M., Huang, Y.-F.*, and Huang, C.-C.,* “Using Rhodamine 6G-modified Gold Nanoparticles to Detect Organic Mercury Species in Highly Saline Solutions.” Environ. Sci. Technol. 2011, 45, 1534-1539.